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Jonathan Towner

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César G Albariño; Ayan K Chakrabarti; Marina L Khristova; Anita McElroy; Stuart T Nichol; Luke S Uebelhoer; Joel P Vincent; Jonathan S Towner
Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolate.
Serena A Carroll; Marina L Khristova; Laura K McMullan; Pierre E Rollin; Tara K Sealy; Robert Swanepoel; Jonathan S Towner; Felicity J Burt; Stuart T Nichol
Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences.
Karoun H Bagamian; James N Mills; Jonathan S Towner; Amy J Kuenzi
Increased detection of Sin Nombre hantavirus RNA in antibody-positive deer mice from Montana, USA: evidence of male bias in RNA viremia.

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All Publications

2013: César G Albariño; Ayan K Chakrabarti; Marina L Khristova; Anita McElroy; Stuart T Nichol; Luke S Uebelhoer; Joel P Vincent; Jonathan S Towner
Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolate.
Virology 2013;446(1-2):230-7.
2013: Serena A Carroll; Marina L Khristova; Laura K McMullan; Pierre E Rollin; Tara K Sealy; Robert Swanepoel; Jonathan S Towner; Felicity J Burt; Stuart T Nichol
Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences.
Journal of virology 2013;87(5):2608-16.
2013: Karoun H Bagamian; James N Mills; Jonathan S Towner; Amy J Kuenzi
Increased detection of Sin Nombre hantavirus RNA in antibody-positive deer mice from Montana, USA: evidence of male bias in RNA viremia.
Viruses 2013;5(9):2320-8.
2012: Brian R Amman; Patrick Atimnedi; Stephen Balinandi; Shelley Campbell; Deborah L Cannon; Serena A Carroll; James A Comer; Robert Downing; Bobbie R Erickson; Timothy D Flietstra; Edward Katongole-Mbidde; Alan Kemp; Marina L Khristova; Thomas G Ksiazek; Stuart T Nichol; Christopher D Paddock; Zachary D Reed; Pierre E Rollin; Tara K Sealy; Robert Swanepoel; Jordan W Tappero; Robert Unfer; Kelly L Warfield; Sherif R Zaki; Rebekah J Kent Crockett; Jonathan S Towner
Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection.
PLoS pathogens 2012;8(10):e1002877.
2011: Jennifer Adjemian; Sam Ahimbisibwe; Brian Amman; Godfrey S Bwire; Emmanuel Byaruhanga; Robert Downing; Eileen C Farnon; Pierre Formenty; Ben Jeffs; Atek Kagirita; Edgar Kansiime; F Katunguka; Julius J Lutwama; Craig Manning; Stuart T Nichol; Jordan W Tappero; Jonathan S Towner; Florimond Tschioko; Joseph F Wamala; Pierre E Rollin
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007.
The Journal of infectious diseases 2011;204 Suppl 3():S796-9.
2010: Adam MacNeil; Eileen C Farnon; Joseph Wamala; Sam Okware; Deborah L Cannon; Zachary Reed; Jonathan S Towner; Jordan W Tappero; Julius Lutwama; Robert Downing; Stuart T Nichol; Thomas G Ksiazek; Pierre E Rollin
Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda.
Emerging infectious diseases 2010;16(12):1969-72.
2009: Jonathan S Towner; Brian R Amman; Tara K Sealy; Serena A Reeder Carroll; James A Comer; Alan Kemp; Robert Swanepoel; Christopher D Paddock; Stephen Balinandi; Marina L Khristova; Pierre Formenty; Cesar G Albarino; David M Miller; Zachary D Reed; John T Kayiwa; James Norman Mills; Deborah L Cannon; Patricia W Greer; Emmanuel Byaruhanga; Eileen C Farnon; Patrick Atimnedi; Samuel Okware; Edward Katongole-Mbidde; Robert Downing; Jordan W Tappero; Sherif R Zaki; Thomas G Ksiazek; Stuart T Nichol; Pierre E Rollin
Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
PLoS pathogens 2009;5(7):e1000536.
2008: Jonathan S Towner; Tara K Sealy; Marina L Khristova; César G Albariño; Sean Conlan; Serena A Reeder; Phenix-Lan Quan; W Ian Lipkin; Robert Downing; Jordan W Tappero; Samuel Okware; Julius Lutwama; Barnabas Bakamutumaho; John Kayiwa; James A Comer; Pierre E Rollin; Thomas G Ksiazek; Stuart T Nichol
Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
PLoS pathogens 2008;4(11):e1000212.
2008: Brian H Bird; Jane W K Githinji; Joseph M Macharia; Jacqueline L Kasiiti; Rees M Muriithi; Stephen G Gacheru; Joseph O Musaa; Jonathan S Towner; Serena A Reeder; Jennifer B Oliver; Thomas L Stevens; Bobbie R Erickson; Laura T Morgan; Marina L Khristova; Amy L Hartman; James A Comer; Pierre E Rollin; Thomas G Ksiazek; Stuart T Nichol
Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007.
Journal of virology 2008;82(22):11152-66.
2008: Amy L Hartman; Brian H Bird; Jonathan S Towner; Zoi-Anna Antoniadou; Sherif R Zaki; Stuart T Nichol
Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus.
Journal of virology 2008;82(6):2699-704.
2007: Jonathan S Towner; Tara K Sealy; Thomas G Ksiazek; Stuart T Nichol
High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settings.
The Journal of infectious diseases 2007;196 Suppl 2():S205-12.
2007: Clayton O Onyango; Martin L Opoka; Thomas G Ksiazek; Pierre Formenty; Abdullahi Ahmed; Peter M Tukei; Rosemary C Sang; Victor O Ofula; Samson L Konongoi; Rodney L Coldren; Thomas Grein; Dominique Legros; Mike Bell; Kevin M De Cock; William Joseph Bellini; Jonathan S Towner; Stuart T Nichol; Pierre E Rollin
Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan, 2004.
The Journal of infectious diseases 2007;196 Suppl 2():S193-8.
2007: Daniel G Bausch; Jonathan S Towner; Scott F Dowell; Felix Kaducu; Matthew Lukwiya; Anthony Sanchez; Stuart T Nichol; Thomas G Ksiazek; Pierre E Rollin
Assessment of the risk of Ebola virus transmission from bodily fluids and fomites.
The Journal of infectious diseases 2007;196 Suppl 2():S142-7.
2007: Jonathan S Towner; Xavier Pourrut; César G Albariño; Chimène Nze Nkogue; Brian H Bird; Gilda Grard; Thomas G Ksiazek; jean paul gonzalez; Stuart T Nichol; Eric M Leroy
Marburg virus infection detected in a common African bat.
PloS one 2007;2(8):e764.
2007: Gustavo Palacios; Phenix-Lan Quan; Omar Jabado; Sean Conlan; David L Hirschberg; Yang Liu; Junhui Zhai; Neil Renwick; Jeffrey Hui; Hedi Hegyi; Allen Grolla; James E Strong; Jonathan S Towner; Thomas W Geisbert; Peter B Jahrling; Cornelia Büchen-Osmond; Heinz Ellerbrok; Maria Paz Sanchez-Seco; Yves lussier; Pierre Formenty; M Stuart T Nichol; Heinz Feldmann; Thomas Briese; W Ian Lipkin
Panmicrobial oligonucleotide array for diagnosis of infectious diseases.
Emerging infectious diseases 2007;13(1):73-81.
2007: Junhui Zhai; Gustavo Palacios; Jonathan S Towner; Omar Jabado; Vishal Kapoor; Marietjie Venter; Allen Grolla; Thomas Briese; Janusz T Paweska; Robert Swanepoel; Heinz Feldmann; Stuart T Nichol; W Ian Lipkin
Rapid molecular strategy for filovirus detection and characterization.
Journal of clinical microbiology 2007;45(1):224-6.
2006: Kavitha Yaddanapudi; Gustavo Palacios; Jonathan S Towner; Ivy Chen; Carlos A Sariol; Stuart T Nichol; W Ian Lipkin
Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2519-30.
2006: Onesmo M Mpanju; Jonathan S Towner; Jason E Dover; Stuart T Nichol; Carolyn A Wilson
Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry.
Virus research 2006;121(2):205-14.
2006: Jonathan S Towner; Marina L Khristova; Tara K Sealy; Martin J Vincent; Bobbie R Erickson; Darcy A Bawiec; Amy L Hartman; James A Comer; Sherif R Zaki; Ute Ströher; Filomena Gomes da Silva; Fernando del Castillo; Pierre E Rollin; Thomas G Ksiazek; Stuart T Nichol
Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola.
Journal of virology 2006;80(13):6497-516.
2006: Amy L Hartman; Jason E Dover; Jonathan S Towner; Stuart T Nichol
Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication.
Journal of virology 2006;80(13):6430-40.
2006: Jens H Kuhn; Sheli R Radoshitzky; Alexander C Guth; Kelly L Warfield; Wenhui Li; Martin J Vincent; Jonathan S Towner; Stuart T Nichol; Sina Bavari; Hyeryun Choe; M Javad Aman; Michael Farzan
Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor.
The Journal of biological chemistry 2006;281(23):15951-8.
2006: Gustavo Palacios; Thomas Briese; Vishal Kapoor; Omar Jabado; Zhiqiang Liu; Marietjie Venter; Junhui Zhai; Neil Renwick; Allen Grolla; Thomas W Geisbert; Christian Drosten; Jonathan S Towner; Jingyue Ju; Janusz T Paweska; Stuart T Nichol; Robert Swanepoel; Heinz Feldmann; Peter B Jahrling; W Ian Lipkin
MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fever.
Emerging infectious diseases 2006;12(4):692-5.
2005: Jonathan S Towner; Jason Paragas; Jason E Dover; Manisha Gupta; Cynthia S Goldsmith; John W Huggins; Stuart T Nichol
Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening.
Virology 2005;332(1):20-7.
2004: Amy L Hartman; Jonathan S Towner; Stuart T Nichol
A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus.
Virology 2004;328(2):177-84.
2004: Jonathan S Towner; Pierre E Rollin; Daniel G Bausch; Anthony Sanchez; Sharon M Crary; Martin Vincent; William F Lee; Christina F Spiropoulou; Thomas G Ksiazek; Matthew Lukwiya; Felix Kaducu; Robert Downing; Stuart T Nichol
Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome.
Journal of virology 2004;78(8):4330-41.
2004: Manisha Gupta; Siddhartha Mahanty; Patricia Greer; Jonathan S Towner; Wun-Ju Shieh; Sherif R Zaki; Rafi Ahmed; Pierre E Rollin
Persistent infection with ebola virus under conditions of partial immunity.
Journal of virology 2004;78(2):958-67.
2003: Jonathan S Towner; David M Brown; Joseph H C Nguyen; Bert L Semler
Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirus.
Virology 2003;314(1):432-42.
2003: Sharon M Crary; Jonathan S Towner; Jessica Honig; Trevor R Shoemaker; Stuart T Nichol
Analysis of the role of predicted RNA secondary structures in Ebola virus replication.
Virology 2003;306(2):210-8.
1998: Jonathan S Towner; Melissa M Mazanet; Bert L Semler
Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins.
Journal of virology 1998;72(9):7191-200.
1998: WS Blair; Todd B Parsley; Hal P Bogerd; Jonathan S Towner; Bert L Semler; Bryan R Cullen
Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases.
RNA (New York, N.Y.) 1998;4(2):215-25.
1997: S Todd; Jonathan S Towner; David M Brown; Bert L Semler
Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions.
Journal of virology 1997;71(11):8868-74.
1997: Todd B Parsley; Jonathan S Towner; LB Blyn; Ellie Ehrenfeld; Bert L Semler
Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase.
RNA (New York, N.Y.) 1997;3(10):1124-34.
1997: LB Blyn; Jonathan S Towner; Bert L Semler; Ellie Ehrenfeld
Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA.
Journal of virology 1997;71(8):6243-6.
1997: S Todd; Jonathan S Towner; Bert L Semler
Translation and replication properties of the human rhinovirus genome in vivo and in vitro.
Virology 1997;229(1):90-7.
1996: Jonathan S Towner; T V Ho; Bert L Semler
Determinants of membrane association for poliovirus protein 3AB.
The Journal of biological chemistry 1996;271(43):26810-8.

CDC Scientists Identify Presence of Marburg Virus in African Fruit Bats

Published: August 23, 2007

Photo: Sabrina Harper, Dominique Wilkins, Quanza Brooks-Griffin, Maurice Madden

CDC Researchers find possible animal source for Marburg virus. (Photo by WHO)

Scientists at the Centers for Disease Control and Prevention and their collaborators have announced that they have successfully identified the presence of Marburg virus in a common species of African fruit bat (R. aegyptiacus). The scientific publication, released on Wednesday, August 22, in the open-access journal PLoS ONE (www.plosone.org), describes an investigation in the Central African countries of Gabon and Democratic Republic of Congo.
Marburg hemorrhagic fever is a severe and highly fatal disease caused by a virus from the same family as the one that causes Ebola hemorrhagic fever. Both diseases are rare, but can cause dramatic outbreaks with high fatality. There is currently no specific treatment or vaccine.
The natural reservoir for Marburg virus has been the cause of much speculation and scientific investigation. Bats have been suspected of carrying the virus, but until now, virus infection in bats had not been documented. It is also the first study to document the existence of Marburg virus in the Central African country of Gabon.

Left: Dr. Brian Amman, medical ecologist for the CDC Special Pathogens Branch. Right: Dr. Jonathan Towner, lead author of the publication, shown here testing bats for the presence of Marburg virus infection. (Photos by WHO)

This paper coincides with an ongoing investigation of Marburg infection among miners in a lead and gold mine in Uganda. The mine, located about 300km from Uganda’s capital, Kampala, provides dwelling for at least two bat species. One is the African fruit bat (R. aegyptiacus), identified in the publication as a potential Marburg carrier.
CDC deployed a six-person team to Uganda in early August to join colleagues from the National Institute of Communicable Diseases (NICD) in South Africa, and the World Health Organization, to investigate the source of the Marburg infection. The team has also been conducting studies to determine if other bat species might also carry the virus.
To learn more about Marburg virus please visit: Marburg Hemorrhagic Fever.

Page last updated: August 23, 2007
Content source: Centers for Disease Control and Prevention

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